References List
Achanta, L. B., & Rae, C. D. (2017). β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms. Neurochemical research, 42(1), 35-49.
Alp, R., Selek, S., Alp, S. I., Taşkin, A. & Koçyiğit, A. Oxidative and antioxidative balance in patients of migraine. European review for medical and pharmacological sciences 14, 877–82 (2010).
Arngrim, N. et al. Migraine induced by hypoxia: an MRI spectroscopy and angiography study. Brain 139, 723–737 (2016).
Arregui, A., Cabrera, J., Leon-Velarde, F., Paredes, S., Viscarra, D., & Arbaiza, D. (1991). High prevalence of migraine in a high-altitude population. Neurology, 41(10), 1668-1668.
Ashina, S., Bentivegna, E., Martelletti, P., & Eikermann-Haerter, K. (2021). Structural and functional brain changes in migraine. Pain and Therapy, 10(1), 211-223.
Aurora, S., Cao, Y., Bowyer, S., & Welch, K. (1999). The occipital cortex is hyperexcitable in migraine: experimental evidence. Headache: The Journal of Head and Face Pain, 39(7), 469-476.
Aytaç, B. et al. Decreased antioxidant status in migraine patients with brain white matter hyperintensities. Neurological Sciences 35, 1925–1929 (2014).
Barbiroli, B. et al. Complicated migraine studied by phosphorus magnetic resonance spectroscopy. Cephalalgia 10, 263–272 (1990).
Barbiroli, B., Montagna, P., Cortelli, P., Funicello, R., Iotti, S., Monari, L., Pierangeli, G., Zaniol, P., & Lugaresi, E. (1992). Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura. Neurology, 42(6), 1209-1209.
Baxter, L. R., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., Gerner, R. H., & Sumida, R. M. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of general psychiatry, 46(3), 243-250.
Becerra, L. et al. A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin 11, 588–594 (2016).
Bernecker, C. et al. Oxidative stress is associated with migraine and migraine-related metabolic risk in females. European journal of neurology 18, 1233–9 (2011).
Binder, C. & Bendtson, I. Endocrine emergencies. Hypoglycaemia. Bailliere’s clinical endocrinology and metabolism 6, 23–39 (1992).
Blau, J. N. & Cumings, J. N. Method of precipitating and preventing some migraine attacks. British medical journal 2, 1242–3 (1966).
Blomqvist, G., Thorell, J., Ingvar, M., Grill, V., Widen, L., & Stone-Elander, S. (1995). Use of R-beta-[1-11C] hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans. American Journal of Physiology-Endocrinology And Metabolism, 269(5), E948-E959.
Brighina, F., Palermo, A., & Fierro, B. (2009). Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine. The journal of headache and pain, 10(2), 77-84.
Bohra, S. K., Achar, R. R., Chidambaram, S. B., Pellegrino, C., Laurin, J., Masoodi, M., & Srinivasan, A. (2022). Current perspectives on mitochondrial dysfunction in migraine. European Journal of Neuroscience.
Boska, M. D., Welch, K. M. A., Barker, P. B., Nelson, J. A., & Schultz, L. (2002). Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes. Neurology, 58(8), 1227-1233.
Bough, K. J., & Rho, J. M. (2007). Anticonvulsant mechanisms of the ketogenic diet. Epilepsia, 48(1), 43-58.
Cavestro, C., Rosatello, A., Micca, G., Ravotto, M., Pia Marino, M., Asteggiano, G., & Beghi, E. (2007). Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache: The Journal of Head and Face Pain, 47(10), 1436-1442.
Ciancarelli, I., Tozzi-Ciancarelli, M., Massimo, C. D., Marini, C. & Carolei, A. Urinary Nitric Oxide Metabolites and Lipid Peroxidation By-Products in Migraine. Cephalalgia 23, 39–42 (2003).
Del Moro, L., Rota, E., Pirovano, E., & Rainero, I. (2022). Migraine, Brain Glucose Metabolism and the “Neuroenergetic” Hypothesis: A Scoping Review. The Journal of Pain.
Denuelle, M., Fabre, N., Payoux, P., Chollet, F. & Geraud, G. Hypothalamic activation in spontaneous migraine attacks. Headache 47, 1418–26 (2007).
Dexter, J. D., Roberts, J. & Byer, J. A. The Five Hour Glucose Tolerance Test and Effect of Low Sucrose Diet in Migraine. Headache: The Journal of Head and Face Pain 18, 91–94 (1978).
Di Lorenzo, C., Coppola, G., Bracaglia, M., Di Lenola, D., Evangelista, M., Sirianni, G., Rossi, P., Di Lorenzo, G., Serrao, M., & Parisi, V. (2016). Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study. The journal of headache and pain, 17(1), 1-10.
Eren, Y., Dirik, E., Neşelioğlu, S., & Erel, Ö. (2015). Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta neurologica belgica, 115(4), 643-649.
Fila, M., Chojnacki, C., & Blasiak, J. (2021). Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine. Nutrients 13(12), 4433.
Geyik, S., Altunısık, E., Neyal, A. M. & Taysi, S. Oxidative stress and DNA damage in patients with migraine. The Journal of Headache and Pain 17, 10 (2016).
Gray, P., & Burtness, H. (1935). Hypoglycemic headache. Endocrinology, 19(5), 549- 560.
Gross, E., Lisicki, M., Fischer, D., Sándor, P., & Schoenen, J. (2019). The metabolic face of migraine—from pathophysiology to treatment. Nature Reviews Neurology, 15(11), 627-643.
Gross, E., Putananickal, N., Orsini, A.-L., Vogt, D., Sandor, P., Schoenen, J., & Fischer, D. (2021). Mitochondrial function and oxidative stress markers in higher- frequency episodic migraine. Scientific reports, 11(1), 1-12.
Gumusyayla, S. et al. A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 37, 1311–7 (2016).
Hertz, L., Chen, Y., & Waagepetersen, H. S. (2015). Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function. Journal of neurochemistry, 134(1), 7-20.
Hockaday, J., Williamson, D., & Whitty, C. (1971). Blood-glucose levels and fatty-acid metabolism in migraine related to fasting. The Lancet, 297(7710), 1153-1156.
Hoffmann, U., Sukhotinsky, I., Eikermann-Haerter, K., & Ayata, C. (2013). Glucose Modulation of Spreading Depression Susceptibility. Journal of Cerebral Blood Flow & Metabolism, 33(2), 191-195.
Holland, S., Silberstein, S. D., Freitag, F., Dodick, D. W., Argoff, C., & Ashman, E. (2012). Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society, 78(17), 1346-1353.
Hsu, L. K. et al. Early morning migraine. Nocturnal plasma levels of catecholamines, tryptophan, glucose, and free fatty acids and sleep encephalographs. Lancet (London, England) 1, 447–51 (1977).
Islam, M. R., & Nyholt, D. R. (2022). Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration. Genes, 13(5), 730.
Jensen, N. J., Wodschow, H. Z., Nilsson, M., & Rungby, J. (2020). Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases. International Journal of Molecular Sciences, 21(22), 8767.
Karatas, H., Erdener, S. E., Gursoy-Ozdemir, Y., Lule, S., Eren-Koçak, E., Sen, Z. D., & Dalkara, T. (2013). Spreading depression triggers headache by activating neuronal Panx1 channels. Science, 339(6123), 1092-1095.
Kesl, S. L., Poff, A. M., Ward, N. P., Fiorelli, T. N., Ari, C., Van Putten, A. J., Sherwood, J. W., Arnold, P., & D’Agostino, D. P. (2016). Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats. Nutrition & Metabolism, 13(1), 9.
Kilic, K., Karatas, H., Dönmez-Demir, B., Eren-Kocak, E., Gursoy-Ozdemir, Y., Can, A., Petit, J. M., Magistretti, P. J., & Dalkara, T. (2018). Inadequate brain glycogen or sleep increases spreading depression susceptibility. Annals of neurology, 83(1), 61-73.
Kim, J. H. et al. Interictal metabolic changes in episodic migraine: A voxel-
based FDG-PET study. Cephalalgia 30, 53–61 (2010).
Kokavec, A. Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences. Physiology & Behavior 142, 170–178 (2015).
Kossoff, E., Zupec-Kania, B. A., Auvin, S., Ballaban-Gil, K. R., Christina Bergqvist, A., Blackford, R., Buchhalter, J. R., Caraballo, R. H., Cross, J. H., & Dahlin, M. G. (2018). Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia open, 3(2), 175-192.
LaManna, J. C., Salem, N., Puchowicz, M., Erokwu, B., Koppaka, S., Flask, C., & Lee, Z. (2009). Ketones suppress brain glucose consumption. In Oxygen Transport to Tissue (pp. 301-306).
Linde, M., Edvinsson, L., Manandhar, K., Risal, A., & Steiner, T. J. (2017). Migraine associated with altitude: results from a population-based study in Nepal. European journal of neurology, 24(8), 1055-1061.
Lisicki, M., D’Ostilio, K., Coppola, G., Scholtes, F., de Noordhout, A. M., Parisi, V., Schoenen, J., & Magis, D. (2018). Evidence of an increased neuronal activation- to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing 18 FDG-PET and visual evoked potentials. The journal of headache and pain, 19(1), 1-9.
Littlewood, J. et al. Low platelet monoamine oxidase activity in headache: no correlation with phenolsulphotransferase, succinate dehydrogenase, platelet preparation method or smoking. Journal of neurology, neurosurgery, and psychiatry 47, 338–43 (1984).
Lodi, R., Iotti, S., Cortelli, P., Pierangeli, G., Cevoli, S., Clementi, V., Soriani, S., Montagna, P., & Barbiroli, B. (2001). Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache. Brain Research Bulletin, 54(4), 437-441.
Lodi, R., Kemp, G., Pierangeli, G., Cortelli, P., Iotti, S., Radda, G., & Barbiroli, B. (1997). Quantitative analysis of skeletal muscle bioenergetics and proton efflux in migraine and cluster headache. Journal of the Neurological Sciences, 146(1), 73-80.
Longo N, Frigeni M, Pasquali M. Carnitine transport and fatty acid oxidation. Biochim Biophys Acta. 2016 Oct;1863(10):2422-35.
Maalouf, M., Rho, J. M., & Mattson, M. P. (2009). The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain research reviews, 59(2), 293-315 Maniyar, F. H., Sprenger, T., Monteith, T., Schankin, C. & Goadsby, P. J. Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain : a journal of neurology 137, 232–41 (2014).
Martins-Oliveira, M., Akerman, S., Holland, P. R., Hoffmann, J. R., Tavares, I.,
& Goadsby, P. J. (2017). Neuroendocrine signaling modulates specific neural networks relevant to migraine. Neurobiology of disease, 101, 16-26.
Meng Shu-Han, S. H., Meng, S. H., Wang, M. X., & Zhao, Y. S. (2021). Dietary Intake of Calcium and Magnesium in Relation to Severe Headache or Migraine. Frontiers in Nutrition, 8. Mergenthaler, P., Lindauer, U., Dienel, G. A., & Meisel, A. (2013). Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends in neurosciences, 36(10), 587-597.
Mohamed, R. E., Aboelsafa, A. A. & Al-Malt, A. M. Interictal alterations of thalamic metabolic concentration ratios in migraine without aura detected by proton magnetic resonance spectroscopy.
The Egyptian Journal of Radiology and Nuclear Medicine 44, 859–870 (2013).
Montagna, P. et al. 31P-magnetic resonance spectroscopy in migraine without aura. Neurology 44, 666–9 (1994).
Montagna, P. et al. Mitochondrial Abnormalities in Migraine. Preliminary Findings. Headache: The Journal of Head and Face Pain 28, 477–480 (1988).
Nehlig, A. (2004). Brain uptake and metabolism of ketone bodies in animal models. Prostaglandins, leukotrienes and essential fatty acids, 70(3), 265-275.
Noh, H. S., Lee, H. P., Kim, D. W., Kang, S. S., Cho, G. J., Rho, J. M., & Choi, W. S. (2004). A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet. Molecular brain research, 129(1-2), Okada, H., Araga, S., Takeshima, T., & Nakashima, K. (1998). Plasma lactic acid and pyruvic acid levels in migraine and tension-type headache. Headache: The Journal of Head and Face Pain, 38(1), 39-42.
Packer, L., Witt, E. H., & Tritschler, H. J. (1995). Alpha-lipoic acid as a biological antioxidant. Free radical biology and medicine, 19(2), 227-250.
Pan, J. W., de Graaf, R. A., Petersen, K. F., Shulman, G. I., Hetherington, H. P., & Rothman, D. L. (2002). [2, 4-13C2]-β-Hydroxybutyrate metabolism in human brain. Journal of Cerebral Blood Flow & Metabolism, 22(7), 890-898. Pierre, K., & Pellerin, L. (2005). Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem, 94(1), 1-14.
Pearce, J. Insulin induced hypoglycaemia in migraine. J. Neurol. Neurosurg. Psychiatry 34, 154–156 (1971).
Plecko, B., Stoeckler-Ipsiroglu, S., Schober, E., Harrer, G., Mlynarik, V., Gruber, S., Moser, E., Moeslinger, D., Silgoner, H., & Ipsiroglu, O. (2002). Oral β-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of β-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. Pediatric Research, 52(2), 301-306.
Poff, A. M., Koutnik, A. P., & Egan, B. (2020). Nutritional Ketosis with Ketogenic Diets or Exogenous Ketones: Features, Convergence, and Divergence. Current Sports Medicine Reports, 19(7).
Prescot, A. et al. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain 5, 34 (2009).
Puchalska, P., & Crawford, P. A. (2017). Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell metabolism, 25(2), 262-284.
Reyngoudt, H., Achten, E. & Paemeleire, K. Magnetic resonance spectroscopy in migraine: what have we learned so far? Cephalalgia : an international journal of headache 32, 845–59 (2012).
Sacco, S. et al. Insulin resistance in migraineurs: Results from a case-control study. Cephalalgia 34, 349–356 (2014).
Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y. & Achten, E. 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. Cephalalgia : an international journal of headache 31, 1243–1253 (2011).
Sampath, A., Kossoff, E. H., Furth, S. L., Pyzik, P. L., & Vining, E. P. (2007). Kidney stones and the ketogenic diet: risk factors and prevention. Journal of child neurology, 22(4), 375-378
Sandor, P., Dydak, U., Schoenen, J., Kollias, S., Hess, K., Boesiger, P., & Agosti, R. (2005). MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura. Cephalalgia, 25(7), 507-518.
Sangiorgi, S., Mochi, M., Riva, R., Cortelli, P., Monari, L., Pierangeli, G., & Montagna, P. (1994). Abnormal platelet mitochondrial function in patients affected by migraine with and without aura. Cephalalgia, 14(1), 21-23.
Schulte, L. H. & May, A. The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 139, 1987–1993 (2016).
Schulz, U., Blamire, A., Corkill, R., Davies, P., Styles, P., & Rothwell, P. (2007). Association between cortical metabolite levels and clinical manifestations of migrainous aura: an MR-spectroscopy study. Brain, 130(12), 3102-3110.
Shaw, S. W., Johnson, R. H. & Keogh, H. J. Metabolic changes during glucose tolerance tests in migraine attacks. Journal of the neurological sciences 33, 51–9 (1977).
Shimomura, T. et al. Platelet Superoxide Dismutase in Migraine and Tension-Type Headache. Cephalalgia 14, 215–218 (1994).
Siva, Z. O., Uluduz, D., Keskin, F. E., Erenler, F., Balcı, H., Uygunoğlu, U., Saip, S., Göksan, B., & Siva, A. (2018). Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine. Cephalalgia, 38(11), 1773-1781.
Slavin, M., Li, H. L., Khatri, M., & Frankenfeld, C. (2021). Dietary magnesium and migraine in adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001-2004. Headache, 61(2), 276-286.
Sokoloff, L. (1973). Metabolism of ketone bodies by the brain. Annual review of medicine, 24(1), 271-280.
Soto-Mota, A., Norwitz, N. G., & Clarke, K. (2020). Why a d-β-hydroxybutyrate monoester? Biochemical Society Transactions, 48(1), 51-59.
Steiner, T. J., Stovner, L. J., Jensen, R., Uluduz, D., & Katsarava, Z. (2020). Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. The Journal of Headache and Pain, 21(1), 1-4.
Stovner, L. J., Nichols, E., Steiner, T. J., Abd-Allah, F., Abdelalim, A., Al-Raddadi, R. M., Ansha, M. G., Barac, A., Bensenor, I. M., Doan, L. P., Edessa, D., Endres, M., Foreman, K. J., Gankpe, F. G., Gopalkrishna, G., Goulart, A. C., Gupta, R., Hankey, G. J., Hay, S. I., Hegazy, M. I., Hilawe, E. H., Kasaeian, A., Kassa, D. H.,
Khalil, I., Khang, Y.-H., Khubchandan, J., Kim, Y. J., Kokubo, Y., Mohammed, M. A., Mokdad, A. H., Moradi-Lakeh, M., Nguyen, H. L. T., Nirayo, Y. L., Qorbani, M., Ranta, A., Roba, K. T., Safiri, S., Santos, I. S., Satpathy, M., Sawhney, M., Shiferaw, M. S., Shiue, I., Smith, M., Szoeke, C. E. I., Truong, N. T., Venketasubramanian, N., weldegwergs, K. g., Westerman, R., Wijeratne, T., Tran, B. X., Yonemoto, N., Feigin, V. L., Vos, T., & Murray, C. J. L. (2018). Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 954-976.
Stubbs, B. J., Cox, P. J., Evans, R. D., Santer, P., Miller, J. J., Faull, O. K., Magor-Elliott, S., Hiyama, S., Stirling, M., & Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Frontiers in physiology, 8, 848.
Suzuki, M., Suzuki, M., Sato, K., Dohi, S., Sato, T., Matsuura, A., & Hiraide, A. (2001). Effect of β-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Japanese journal of pharmacology, 87(2), 143-150.
Svart, M., Gormsen, L. C., Hansen, J., Zeidler, D., Gejl, M., Vang, K., Aanerud, J., & Moeller, N. (2018). Regional cerebral effects of ketone body infusion with 3- hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial. PLoS One, 13(2), e0190556.
Takano, T., Tian, G.-F., Peng, W., Lou, N., Lovatt, D., Hansen, A. J., Kasischke, K. A., & Nedergaard, M. (2007). Cortical spreading depression causes and coincides with tissue hypoxia. Nature neuroscience, 10(6), 754-762.
Watanabe, H., Kuwabara, T., Ohkubo, M., Tsuji, S., & Yuasa, T. (1996). Elevation of cerebral lactate detected by localized sup 1 H-magnetic resonance spectroscopy in migraine during the interictal period. Neurology, 47(4), 1093-1095.
Tozzi-Ciancarelli, M. et al. Oxidative Stress and Platelet Responsiveness in Migraine. Cephalalgia 17, 580–584 (1997).
Tripathi, G. M., Kalita, J. & Misra, U. K. A study of oxidative stress in migraine with special reference to prophylactic therapy. The International journal of neuroscience 128, 318–324 (2018).
Tuncel, D., Tolun, F. I., Gokce, M., İmrek, S. & Ekerbiçer, H. Oxidative Stress in Migraine with and Without Aura. Biological Trace Element Research 126, 92–97 (2008).